Ubiquitylation of lipopolysaccharide by RNF213 during bacterial infection

Nature, Published online: 19 May 2021; doi:10.1038/s41586-021-03566-4

Upon Salmonella invasion of the mammalian cytosol, ubiquitylation of a non-proteinaceous substrate—the lipid A moiety of bacterial lipopolysaccharide—by the E3 ubiquitin ligase RNF213 marks the bacteria as cargo for antibacterial autophagy.