NF1 mutation drives neuronal activity-dependent initiation of optic glioma

Nature, Published online: 26 May 2021; doi:10.1038/s41586-021-03580-6

Mouse models of NF1-associated optic pathway glioma show that tumour initiation and growth are driven by aberrantly high levels of NLGN3 shedding in the optic nerve in response to retinal neuron activity.