Sensory neuron-derived TAFA4 promotes macrophage tissue repair functions

Nature, Published online: 19 May 2021; doi:10.1038/s41586-021-03563-7

Specialized somatosensory neurons that express Gαi-interacting protein (GINIP) promote tissue repair in a model of UV-induced skin damage by secreting the neuropeptide TAFA4, which regulates skin-resident macrophages to release IL-10 and limit fibrosis.

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