MIR-NATs repress MAPT translation and aid proteostasis in neurodegeneration

Nature, Published online: 19 May 2021; doi:10.1038/s41586-021-03556-6

The natural antisense transcript MAPT-AS1 interferes with translation of mRNA transcript into tau protein in the brain and may represent a general mechanism for controlling levels of intrinsically disordered proteins, with particular relevance for neurodegeneration.

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