MARK4 controls ischaemic heart failure through microtubule detyrosination

Nature, Published online: 26 May 2021; doi:10.1038/s41586-021-03573-5

MARK4 regulates cardiomyocyte contractility by promoting MAP4 phosphorylation, which facilitates the access of VASH2 to microtubules for the detyrosination of α-tubulin; MARK4 deficiency after acute myocardial infarction limits the reduction in the left ventricular ejection fraction.

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