Site-specific RNA methylation by a methyltransferase ribozyme

Nature, Published online: 28 October 2020; doi:10.1038/s41586-020-2854-z

A methyltransferase ribozyme, along with the small-molecule cofactor O6-methylguanine, is shown to catalyse the site-specific installation of 1-methyladenosine in various RNAs, providing insights into the catalytic abilities of RNA.

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