DNA mismatches reveal conformational penalties in protein–DNA recognition

Nature, Published online: 21 October 2020; doi:10.1038/s41586-020-2843-2

A high-throughput assay that introduces mismatched base pairs into the DNA sequence shows that mismatches can increase transcription factor binding affinity by prepaying some of the energetic cost of distorting the DNA.

Comments

Post a Comment

Popular posts from this blog

Photo Of The Day By Valerie Millett

Image
Photo By Valerie Millett Today’s Photo Of The Day is “Red Rock Winter” by Valerie Millett. Location: Coconino National Forest, Arizona. Photo of the Day is chosen from various OP galleries, including  Assignments ,  Galleries  and the  OP Contests . Assignments have weekly winners that are featured on the OP website homepage,  Facebook ,  Twitter  and  Instagram . To get your photos in the running, all you have to do is submit them. The post Photo Of The Day By Valerie Millett appeared first on Outdoor Photographer .
Read more