Exuberant fibroblast activity compromises lung function via ADAMTS4

Nature, Published online: 28 October 2020; doi:10.1038/s41586-020-2877-5

Viral infection of the respiratory system induces exuberant fibroblast activity, resulting in extensive remodelling of the extracellular matrix and cytokine release, which promote immune cell infiltration of the affected area at the expense of respiratory function.