Metabolic control of BRISC–SHMT2 assembly regulates immune signalling

Nature, Published online: 29 May 2019; doi:10.1038/s41586-019-1232-1

Cryo-electron microscopy and mutation experiments demonstrate that the inactive SHMT2 dimer—and not the pyridoxal-5′-phosphate-bound tetramer—binds to BRISC, which reveals a mechanism for the regulation of deubiquitylases and inflammatory signalling.

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