Design and evolution of an enzyme with a non-canonical organocatalytic mechanism

Nature, Published online: 27 May 2019; doi:10.1038/s41586-019-1262-8

A hydrolytic enzyme with a non-canonical organocatalytic mechanism was generated by introducing Nδ-methylhistidine through the cellular translation machinery into a designed active site, allowing optimization of enzyme performance using laboratory evolution protocols adapted to an expanded genetic code.

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