Structure of the IFNγ receptor complex guides design of biased agonists

Structure of the IFNγ receptor complex guides design of biased agonists

Structure of the IFNγ receptor complex guides design of biased agonists, Published online: 27 February 2019; doi:10.1038/s41586-019-0988-7

The X-ray structure of the hexameric complex of interferon-γ bound to its receptors is solved at 3.25 Å resolution, providing a basis for engineering variants of interferon-γ that enable decoupling of its immunomodulatory functions.

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