Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche

Breast cancer cells rely on environmental pyruvate to shape the metastatic niche, Published online: 27 February 2019; doi:10.1038/s41586-019-0977-x

Exogenous pyruvate is needed for breast cancer cells to form metastases, and the inhibition of pyruvate metabolism impairs collagen hydroxylation and the growth of lung metastases in different mouse models.

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