NR4A transcription factors limit CAR T cell function in solid tumours

NR4A transcription factors limit CAR T cell function in solid tumours

NR4A transcription factors limit CAR T cell function in solid tumours, Published online: 27 February 2019; doi:10.1038/s41586-019-0985-x

Transfer of NR4A-deficient T cells expressing chimeric antigen receptors is shown to reduce tumour burden and increase survival by shifting T cell transcriptional programs away from exhaustion and towards increased effector function.

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