Genetic and functional insights into the fractal structure of the heart

Nature, Published online: 19 August 2020; doi:10.1038/s41586-020-2635-8

A genome-wide association study shows that myocardial trabeculae are an important determinant of cardiac performance in the adult heart, identifies conserved pathways that regulate structural complexity and reveals the influence of trabeculae on the susceptibility to cardiovascular disease.