C9orf72 in myeloid cells suppresses STING-induced inflammation

Nature, Published online: 19 August 2020; doi:10.1038/s41586-020-2625-x

Studies of mice and humans suggest a role for loss of the C9orf72 protein in some neurodegenerative disorders: with reduced C9orf72 levels, there is more inflammation mediated by the STING protein in immune and brain cells.