ILC3s select microbiota-specific regulatory T cells to establish tolerance in the gut

Nature, Published online: 07 September 2022; doi:10.1038/s41586-022-05141-x

ILC3s expressing MHC class II control the fate of inflammatory versus tolerogenic T cells that respond to the microbiota by selecting for antigen-specific RORγt+ Treg cells and against TH17 cells, establishing intestinal homoeostasis.