Structures of full-length glycoprotein hormone receptor signalling complexes

Nature, Published online: 22 September 2021; doi:10.1038/s41586-021-03924-2

Cryo-electron microscopy structures of the luteinizing hormone–choriogonadotropin receptor (LHCGR), in complex with Gs and in various states of activation, reveal a distinct mechanism of receptor activation, with implications for drug discovery.