Structural strains of misfolded tau protein define different diseases

Nature, Published online: 29 September 2021; doi:10.1038/d41586-021-02611-6

In diseases called tauopathies, misfolded tau proteins form aggregates called fibrils. Fibrils from nine different tauopathies show that tau misfolds in many ways, enabling the diseases to be classified according to fibril structure.

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