Whole-genome doubling confers unique genetic vulnerabilities on tumour cells

Nature, Published online: 27 January 2021; doi:10.1038/s41586-020-03133-3

Cancer cells that have undergone whole-genome doubling are more reliant than their near-diploid counterparts on DNA-replication factors, the spindle-assembly checkpoint and a mitotic kinesin protein, KIF18A.

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