Integrated spatial genomics reveals global architecture of single nuclei

Nature, Published online: 27 January 2021; doi:10.1038/s41586-020-03126-2

Multiplexed imaging of 3,660 chromosomal loci in individual mouse embryonic stem cells by DNA seqFISH+ with immunofluorescence of 17 chromatin marks and subnuclear structures reveals invariant organization of loci within individual cells, and heterogeneous and long-lived distinct combinatorial chromatin states in cellular subpopulations.

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