Small-molecule-induced polymerization triggers degradation of BCL6

Nature, Published online: 18 November 2020; doi:10.1038/s41586-020-2925-1

Binding of the small molecule BI-3802 to the oncogenic transcription factor B cell lymphoma 6 (BCL6) induces polymerization of BCL6, leading to its ubiquitination by SIAH1 and proteasomal degradation.

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