Single-molecule imaging of transcription dynamics in somatic stem cells

Nature, Published online: 24 June 2020; doi:10.1038/s41586-020-2432-4

Single-molecule fluorescence in situ hybridization and live-cell imaging are used to study the contribution of transcriptional noise to stem cell heterogeneity, revealing that stochastic transcription dynamics are conducive to concomitant stem-cell maintenance and tissue homeostasis.

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