Reversing a model of Parkinson’s disease with in situ converted nigral neurons

Nature, Published online: 24 June 2020; doi:10.1038/s41586-020-2388-4

Depletion of the RNA-binding protein PTB (also known as PTBP1) in astrocytes reprograms these cells to become functional neurons and, in a mouse model of Parkinson’s disease, reverses the disease phenotype.

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