A sensory appendage protein protects malaria vectors from pyrethroids

Nature, Published online: 25 December 2019; doi:10.1038/s41586-019-1864-1

The leg-enriched sensory appendage protein, SAP2, confers pyrethroid resistance to Anopheles gambiae, through high-affinity binding of pyrethroid insecticides; an observed selective sweep in field mosquitoes mirrors the increasing resistance reported in Africa.