Dietary methionine influences therapy in mouse cancer models and alters human metabolism

Nature, Published online: 31 July 2019; doi:10.1038/s41586-019-1437-3

In two patient-derived xenograft models of colorectal cancer and a mouse model of autochthonous soft-tissue sarcoma, dietary restriction of methionine influences the outcome of cancer and interacts with antimetabolite and radiation therapies, through effects on one-carbon metabolism.