Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport

Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport

Serotonin transporter–ibogaine complexes illuminate mechanisms of inhibition and transport, Published online: 24 April 2019; doi:10.1038/s41586-019-1135-1

Cryo-electron microscopy reveals three conformations of the serotonin transporter in complex with ibogaine, detailing the structural rearrangements that occur between the different stages of its transport cycle.