NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling

NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling

NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling, Published online: 24 April 2019; doi:10.1038/s41586-019-1150-2

NAD metabolic pathway choice in cancer is largely dependent on the tissue of origin, with implications for the development of precision treatments.