PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress, Published online: 30 January 2019; doi:10.1038/s41586-019-0895-y

Phosphorylation of one of two adjacent serine residues in TSC2 is both required and sufficient for PKG1-mediated cardiac protection against pressure overload in mice; these serine residues provide a genetic tool for the bidirectional regulation of stress-stimulated mTORC1 activity.