Heterozygous mutations cause genetic instability in a yeast model of cancer evolution

Heterozygous mutations cause genetic instability in a yeast model of cancer evolution

Heterozygous mutations cause genetic instability in a yeast model of cancer evolution, Published online: 30 January 2019; doi:10.1038/s41586-019-0887-y

Repeated selection for adaptive mutations in a diploid yeast model results in increased genetic instability and sheds light on mechanisms of genetic instability that might contribute to tumorigenesis.