NATURE

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Forget everything you know about 3D printing — the ‘replicator’ is here Forget everything you know about 3D printing — the ‘replicator’ is here, Published online: 31 January 2019; doi:10.1038/d41586-018-07798-9 Rather than building objects layer by layer, the printer creates whole structures by projecting light into a resin that solidifies.

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Daily briefing: Learn to take exceptional scientific photos Daily briefing: Learn to take exceptional scientific photos, Published online: 31 January 2019; doi:10.1038/d41586-019-00409-1 You only need a mobile phone or a flatbed scanner. Plus: Neanderthals and Denisovans lived together in Denisova Cave and how Hollywood can get climate change right.

How machine learning could keep dangerous DNA out of terrorists' hands How machine learning could keep dangerous DNA out of terrorists' hands, Published online: 31 January 2019; doi:10.1038/d41586-019-00277-9 Sophisticated algorithms could help DNA-synthesis companies avoid making dangerous organisms on demand.

Battle over when giant pandas started their bamboo diet heats up Battle over when giant pandas started their bamboo diet heats up, Published online: 31 January 2019; doi:10.1038/d41586-019-00301-y Switch to such restricted fare probably happened thousands of years ago, not millions, as some research has suggested.

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How to land a journal cover How to land a journal cover, Published online: 31 January 2019; doi:10.1038/d41586-019-00349-w Kelly Krause extols a handbook on the art and science of the research photo shoot from Felice Frankel.

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How to write effectively for international journals How to write effectively for international journals, Published online: 30 January 2019; doi:10.1038/d41586-019-00359-8 Use modern tools to manage research literature, analyse published articles and find language teachers to improve manuscripts for publication.

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Podcast: Women of the periodic table, and harvesting energy from Wi-Fi Podcast: Women of the periodic table, and harvesting energy from Wi-Fi, Published online: 30 January 2019; doi:10.1038/d41586-019-00354-z Hear the latest science news, brought to you by Benjamin Thompson and Noah Baker.

Heterozygous mutations cause genetic instability in a yeast model of cancer evolution Heterozygous mutations cause genetic instability in a yeast model of cancer evolution, Published online: 30 January 2019; doi:10.1038/s41586-019-0887-y Repeated selection for adaptive mutations in a diploid yeast model results in increased genetic instability and sheds light on mechanisms of genetic instability that might contribute to tumorigenesis.

Timing of archaic hominin occupation of Denisova Cave in southern Siberia Timing of archaic hominin occupation of Denisova Cave in southern Siberia, Published online: 30 January 2019; doi:10.1038/s41586-018-0843-2 Optical dating of sediments from Denisova Cave establishes a chronology for its Pleistocene deposits and the associated artefacts, hominin remains and environmental records, which date to between about 300,000 and 20,000 years ago.

Secondary organic aerosol reduced by mixture of atmospheric vapours Secondary organic aerosol reduced by mixture of atmospheric vapours, Published online: 30 January 2019; doi:10.1038/s41586-018-0871-y Adding reactive gases such as isoprene to mixtures lowers the production of secondary organic aerosol in the atmosphere, thus reducing the atmospheric particulate burden, with implications for human health and climate.

One rogue agent suffices for genomic chaos One rogue agent suffices for genomic chaos, Published online: 30 January 2019; doi:10.1038/d41586-019-00260-4 Genetic instability is a hallmark of cancer cells, and occurs when genes required for genomic maintenance are inactivated. It emerges that altering just one of the two copies of certain genes can drive genetic instability in yeast.

Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease Gut intraepithelial T cells calibrate metabolism and accelerate cardiovascular disease, Published online: 30 January 2019; doi:10.1038/s41586-018-0849-9 Integrin β7-dependent Glp1rhigh natural gut intraepithelial T lymphocytes that reside in the small intestine modulate dietary metabolism in mice by restricting the bioavailability of GLP-1.

A quantitative approach for measuring the reservoir of latent HIV-1 proviruses A quantitative approach for measuring the reservoir of latent HIV-1 proviruses, Published online: 30 January 2019; doi:10.1038/s41586-019-0898-8 An assay to measure the latent HIV-1 reservoir that separately quantifies intact and defective proviruses will facilitate evaluation of HIV-1 cure strategies by measuring the provirues that pose a barrier to cure.

Atmospheric reaction networks affecting climate are more complex than was thought Atmospheric reaction networks affecting climate are more complex than was thought, Published online: 30 January 2019; doi:10.1038/d41586-019-00263-1 Experiments show that the amount of atmospheric particles produced from plant emissions could be lower than was thought — challenging our understanding of the processes that affect air quality and climate.

FOXK1 and FOXK2 regulate aerobic glycolysis FOXK1 and FOXK2 regulate aerobic glycolysis, Published online: 30 January 2019; doi:10.1038/s41586-019-0900-5 The Forkhead transcription factors FOXK1 and FOXK2, which are induced by starvation, reprogram cellular metabolism to induce aerobic glycolysis.

Gut immune cells have a role in food metabolism Gut immune cells have a role in food metabolism, Published online: 30 January 2019; doi:10.1038/d41586-019-00235-5 The gut is an active site of immune defence against disease-causing microbes. A study in mice shows that a type of immune cell in the gut’s wall also helps to regulate sugar and fat metabolism.

Ancient-human species mingled in Siberia’s hottest property for 300,000 years Ancient-human species mingled in Siberia’s hottest property for 300,000 years, Published online: 30 January 2019; doi:10.1038/d41586-019-00353-0 Neanderthals and Denisovans both called Denisova Cave home — and Homo sapiens might have, too.

Onset of differentiation is post-transcriptionally controlled in adult neural stem cells Onset of differentiation is post-transcriptionally controlled in adult neural stem cells, Published online: 30 January 2019; doi:10.1038/s41586-019-0888-x Sequencing of total and ribosome-associated mRNAs enables identification of specific mRNAs that are differentially translationally regulated along the neuronal stem cell lineage, independently of their availability.

How Brexit threatens Irish science’s cross-border collaboration How Brexit threatens Irish science’s cross-border collaboration, Published online: 30 January 2019; doi:10.1038/d41586-019-00339-y Peace and common membership of the European Union have allowed scientists in the Republic of Ireland and Northern Ireland to build a unique, cross-border research system.

Complex networks reveal global pattern of extreme-rainfall teleconnections Complex networks reveal global pattern of extreme-rainfall teleconnections, Published online: 30 January 2019; doi:10.1038/s41586-018-0872-x Complex networks are used to analyse global-scale teleconnections between extreme-rainfall events, revealing a peak in the distance distribution of statistically significant connections at around 10,000 kilometres.

PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress PKG1-modified TSC2 regulates mTORC1 activity to counter adverse cardiac stress, Published online: 30 January 2019; doi:10.1038/s41586-019-0895-y Phosphorylation of one of two adjacent serine residues in TSC2 is both required and sufficient for PKG1-mediated cardiac protection against pressure overload in mice; these serine residues provide a genetic tool for the bidirectional regulation of stress-stimulated mTORC1 activity.

Experimentally trained statistical models boost nuclear-fusion performance Experimentally trained statistical models boost nuclear-fusion performance, Published online: 30 January 2019; doi:10.1038/d41586-019-00261-3 Research into a technique called inertial confinement fusion aims to enhance nuclear-fusion performance in laboratory experiments. Improvements in the technique have been made using a clever statistical approach.

Atomically dispersed iron hydroxide anchored on Pt for preferential oxidation of CO in H 2 Atomically dispersed iron hydroxide anchored on Pt for preferential oxidation of CO in H₂, Published online: 30 January 2019; doi:10.1038/s41586-018-0869-5 Atomically dispersed iron hydroxide deposited on silica-supported platinum nanoparticles enables complete and selective carbon monoxide removal through preferential oxidation in hydrogen in the temperature range from 198 to 380 kelvin.

Signalling protein protects the heart muscle from pressure-related stress Signalling protein protects the heart muscle from pressure-related stress, Published online: 30 January 2019; doi:10.1038/d41586-019-00245-3 If blood flow from the heart is impeded, the pressure created causes tissue dysfunction. It emerges that different signals converge on the TSC2 and mTOR proteins to fine-tune the response of heart cells to stress.

Interleukin-22 protects intestinal stem cells against genotoxic stress Interleukin-22 protects intestinal stem cells against genotoxic stress, Published online: 30 January 2019; doi:10.1038/s41586-019-0899-7 Sporadic inactivation of the interleukin-22 receptor in the intestinal epithelium of the mouse shows that IL-22 is required for effective activation of the DNA damage response following DNA damage.

Dating of hominin discoveries at Denisova Dating of hominin discoveries at Denisova, Published online: 30 January 2019; doi:10.1038/d41586-019-00264-0 Denisova Cave sheltered hominins at least 200,000 years ago, and excavations there have illuminated our understanding of early hominins in Asia. New dating analyses now refine this knowledge.

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Units reform harks back to US president Jefferson Units reform harks back to US president Jefferson, Published online: 30 January 2019; doi:10.1038/d41586-019-00326-3 Units reform harks back to US president Jefferson

UN could lead debate on gene editing UN could lead debate on gene editing, Published online: 30 January 2019; doi:10.1038/d41586-019-00324-5 UN could lead debate on gene editing

Protect Madagascar’s national parks from pillage Protect Madagascar’s national parks from pillage, Published online: 30 January 2019; doi:10.1038/d41586-019-00322-7 Protect Madagascar’s national parks from pillage

Per capita carbon emissions must fall to 1955 levels Per capita carbon emissions must fall to 1955 levels, Published online: 30 January 2019; doi:10.1038/d41586-019-00325-4 Per capita carbon emissions must fall to 1955 levels

Brexit impacts, quitting coal and Lassa-fever outbreak Brexit impacts, quitting coal and Lassa-fever outbreak, Published online: 30 January 2019; doi:10.1038/d41586-019-00283-x The week in science: 25–31 January 2019.

Brand Madagascar’s rosewood and ebony as endangered Brand Madagascar’s rosewood and ebony as endangered, Published online: 30 January 2019; doi:10.1038/d41586-019-00323-6 Brand Madagascar’s rosewood and ebony as endangered

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