The power of genetic diversity in genome-wide association studies of lipids

Nature, Published online: 09 December 2021; doi:10.1038/s41586-021-04064-3

A genome-wide association meta-analysis study of blood lipid levels in roughly 1.6 million individuals demonstrates the gain of power attained when diverse ancestries are included to improve fine-mapping and polygenic score generation, with gains in locus discovery related to sample size.