Structural insights into Ubr1-mediated N-degron polyubiquitination

Nature, Published online: 17 November 2021; doi:10.1038/s41586-021-04097-8

Structures of Ubr1 in complex with Ubc2, ubiquitin and two N-degron peptides reveal a Ubc2-binding region and an acceptor ubiquitin-binding loop on Ubr1, providing mechanistic insights into the initiation and elongation steps of ubiquitination catalysed by Ubr1.