The structure of neurofibromin isoform 2 reveals different functional states

Nature, Published online: 27 October 2021; doi:10.1038/s41586-021-04024-x

Cryo-EM structure of Nf1 protein is reported, revealing closed and open conformations that regulate interaction with Ras oncogene, setting the stage for understanding the mechanistic action of Nf1 and how disease mutations lead to dysfunction.

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