Aneuploidy renders cancer cells vulnerable to mitotic checkpoint inhibition

Nature, Published online: 27 January 2021; doi:10.1038/s41586-020-03114-6

Aneuploid cancer cell lines show increased dependence on the spindle assembly complex (SAC); initially they are resistant to SAC perturbations, but over time they accumulate chromosomal aberrations that impair their fitness.

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