Histone H3.3 phosphorylation amplifies stimulation-induced transcription

Nature, Published online: 22 July 2020; doi:10.1038/s41586-020-2533-0

The histone variant H3.3 is phosphorylated at Ser31 in induced genes, and this selective mark stimulates the histone methyltransferase SETD2 and ejects the ZMYND11 repressor, thus revealing a role for histone phosphorylation in amplifying de novo transcription.

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