Structural basis of the activation of a metabotropic GABA receptor

Nature, Published online: 17 June 2020; doi:10.1038/s41586-020-2408-4

Cryo-electron microscopy structures of apo, agonist- and positive allosteric modulator-bound forms of the GB1–GB2 heterodimer of the metabotropic γ-aminobutyric acid (GABA) receptor shed light on the activation mechanism of this receptor.