Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+

Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+

Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH+, Published online: 25 March 2019; doi:10.1038/s41586-019-1049-y

seqFISH+, an evolution of sequential fluorescence in situ hybridization with super-resolution imaging capabilities, is used to image mRNAs of 10,000 genes in cultured cells and mouse brain slices, demonstrating the ability to generate spatial atlases and to perform discovery-driven studies in situ.