Stochastic synaptic plasticity underlying compulsion in a model of addiction

Stochastic synaptic plasticity underlying compulsion in a model of addiction

Stochastic synaptic plasticity underlying compulsion in a model of addiction, Published online: 19 December 2018; doi:10.1038/s41586-018-0789-4

In mice, synaptic potentiation of transmission from the orbitofrontal cortex to the dorsal striatum drives compulsive reinforcement, a defining symptom of addiction.