Life histories of myeloproliferative neoplasms inferred from phylogenies

Nature, Published online: 20 January 2022; doi:10.1038/s41586-021-04312-6

Whole-genome sequencing of 1,013 clonal haematopoietic colonies from myeloproliferative neoplasms of 12 individuals reveals haematopoietic phylogenies and indicates that driver mutations are acquired sequentially, starting early in life.