Two chemoattenuated PfSPZ malaria vaccines induce sterile hepatic immunity

Nature, Published online: 30 June 2021; doi:10.1038/s41586-021-03684-z

Two malaria vaccines comprising Plasmodium falciparum sporozoites and treatment with either pyrimethamine or chloroquine induced durable protective responses against both the African vaccine strain and a heterologous South American strain of P. falciparum.