Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases

Nature, Published online: 23 December 2020; doi:10.1038/s41586-020-03069-8

Cryo-electron microscopy structures of the nucleosome-bound NSD2 and NSD3 histone methyltransferases reveal the molecular basis of their histone modification activity, and show how mutations in these proteins can lead to oncogenesis.