Repeat expansions confer WRN dependence in microsatellite-unstable cancers

Nature, Published online: 30 September 2020; doi:10.1038/s41586-020-2769-8

In cells with microsatellite instability, expanded TA-dinucleotide repeats form cruciform structures that stall replication forks and cause chromosome shattering in the absence of the WRN helicase.