Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Nature, Published online: 22 April 2020; doi:10.1038/s41586-020-2229-5

Inhibition of the autophagy–lysosome system upregulates surface expression of MHC class I proteins and enhances antigen presentation, and evokes a potent anti-tumour immune response that is mediated by CD8+ T cells.