Gut stem cell necroptosis by genome instability triggers bowel inflammation

Nature, Published online: 25 March 2020; doi:10.1038/s41586-020-2127-x

In mouse models of bowel inflammation, depletion of the SETDB1 histone methyltransferase leads to genome instability, which releases repression of endogenous retroviruses that triggers ZBP1-dependent necroptosis and inflammation in gut.