Epigenetic therapy inhibits metastases by disrupting premetastatic niches

Nature, Published online: 26 February 2020; doi:10.1038/s41586-020-2054-x

In mouse models of pulmonary metastasis, adjuvant epigenetic therapy targeting myeloid-derived suppressor cells disrupts the premetastatic microenvironment after resection of primary tumours and inhibits the dissemination of residual tumour cells.