The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity

Nature, Published online: 30 October 2019; doi:10.1038/s41586-019-1694-1

Treatment of KRASG12C-mutant cancer cells with the KRAS(G12C) inhibitor AMG 510 leads to durable response in mice, and anti-tumour activity in patients suggests that AMG 510 could be effective in patients for whom treatments are currently lacking.

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