Structural basis of Notch recognition by human γ-secretase

Structural basis of Notch recognition by human γ-secretase

Structural basis of Notch recognition by human γ-secretase, Published online: 31 December 2018; doi:10.1038/s41586-018-0813-8

The cryo-electron microscopy structure of human γ-secretase in complex with its substrate Notch reveals pronounced structural rearrangements compared to the apo enzyme, including formation of a β-sheet involving residues from both enzyme and substrate.