NATURE

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Tissue-resident memory CD8 + T cells promote melanoma–immune equilibrium in skin Tissue-resident memory CD8⁺ T cells promote melanoma–immune equilibrium in skin, Published online: 31 December 2018; doi:10.1038/s41586-018-0812-9 A transplantable mouse model of persistent cutaneous melanoma shows that immune-mediated tumour suppression can result in a state of melanoma–immune equilibrium, and that tissue-resident memory T cells are essential drivers of this equilibrium state.

Structural basis of Notch recognition by human γ-secretase Structural basis of Notch recognition by human γ-secretase, Published online: 31 December 2018; doi:10.1038/s41586-018-0813-8 The cryo-electron microscopy structure of human γ-secretase in complex with its substrate Notch reveals pronounced structural rearrangements compared to the apo enzyme, including formation of a β-sheet involving residues from both enzyme and substrate.

Structure of the post-translational protein translocation machinery of the ER membrane Structure of the post-translational protein translocation machinery of the ER membrane, Published online: 31 December 2018; doi:10.1038/s41586-018-0856-x Structure of the post-translational protein translocation machinery of the ER membrane

A warped disk around an infant protostar A warped disk around an infant protostar, Published online: 31 December 2018; doi:10.1038/s41586-018-0819-2 Observations at millimetre wavelengths reveal a young protostar surrounded by a disk with two differently tilted regions.

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There are many rules and guidelines that relate to art. They correspond to composition, light, depth of field, color harmony, sharpness and so much more. They’re written and applied for good reason. The rule of thirds should be applied to create a successful composition. Mid-day light doesn’t work that well for a grand scenic, so it should be avoided. Always freeze motion when you capture action, etc. There are many rules that govern us and if they’re broken, a penalty has to be paid. The beauty of art is that rules can constantly be challenged to test their credibility. So throw caution to the wind, dust off your Break the Rules sneakers, be a rebel and make the mutiny bountiful. Test the waters to find an exception where breaking the rule nets you a fantastic image. In regard to photography, “rules” and “guidelines” are used interchangeably. If you’re a very regimented person, this is a relief. A guideline infers a suggested path while a rule connotes a dictated path. So exhale, ...

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Three steps to landing an undergraduate research internship Three steps to landing an undergraduate research internship, Published online: 28 December 2018; doi:10.1038/d41586-018-07830-y Personalized recommendations and a solid science background are crucial, say Ruth Gotian and Ushma S. Neill.

Hot tickets for scientists in 2019: Nature ’s pick of the cultural calendar Hot tickets for scientists in 2019: <i>Nature</i>’s pick of the cultural calendar, Published online: 28 December 2018; doi:10.1038/d41586-018-07849-1 Food and the gut go on show, Angolan ‘sea monsters’ resurface and Alexander von Humboldt pops into focus. Nicola Jones reports.

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Podcast: Our reporters' top picks of 2018 Podcast: Our reporters' top picks of 2018, Published online: 26 December 2018; doi:10.1038/d41586-018-07866-0 Find out about the fate of the Baobab tree, what it's like to win a Nobel Prize, and the shape of memories.

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The word portrait conjures up visions of a face of an animal, a frame-filling full body shot or another up close and personal recording of the species. Typically, the goal is to reveal character aspects, an adorable expression or to show off the regal features of a majestic coat or colorful feathers. Ideally, the background will be out of focus so the subject stands out with no distractions. A long lens and wide-open aperture are often used to accomplish this effect. I absolutely make it a goal to make the above kinds of photos, but if I solely concentrate on them, there’s an entire category of photos I deprive myself of capturing. I wind up limiting my portfolio for the sake of adding a single type of image to my files. From an economic standpoint, this isn't wise. If you’re lucky enough to go on a safari to the Serengeti, a frame-filling image of a zebra would be high on your list. They have character, the lines on their faces are intriguing and close up patterns of their hid...