NATURE

Light pulses prod artificial muscle into action Light pulses prod artificial muscle into action, Published online: 30 November 2018; doi:10.1038/d41586-018-07582-9 An optical signal triggers mechanical motion thanks to a nerve junction constructed in the laboratory.

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Tehran’s drastic sinking exposed by satellite data Tehran’s drastic sinking exposed by satellite data, Published online: 30 November 2018; doi:10.1038/d41586-018-07580-x Parts of Iran’s capital city, home to 13 million people, are subsiding by 25 centimetres each year.

Daily briefing: 6 things we want to know following CRISPR baby claims Daily briefing: 6 things we want to know following CRISPR baby claims, Published online: 30 November 2018; doi:10.1038/d41586-018-07620-6 So many questions following this week’s spectacular claims. Plus, getting the dirt on a tiny asteroid, the UN rules on gene-drives, and how to protect Venice from flood waters.

Black holes, shark skin and cockatoo tools — November’s best science images Black holes, shark skin and cockatoo tools — November’s best science images, Published online: 30 November 2018; doi:10.1038/d41586-018-07599-0 The month’s sharpest science shots — selected by Nature’s photo team.

Moon exploration is back in fashion as nations vie in space race Moon exploration is back in fashion as nations vie in space race, Published online: 30 November 2018; doi:10.1038/d41586-018-07568-7 As China’s Chang'-4 mission is about to head off to the far side of the Moon, Nature looks at the history and future of lunar missions.

First CRISPR babies: 6 questions that remain First CRISPR babies: 6 questions that remain, Published online: 30 November 2018; doi:10.1038/d41586-018-07607-3 Startling human-genome editing claim leaves many open questions, from He Jiankui's next move to the future of the field.

China set to launch first-ever spacecraft to the far side of the Moon China set to launch first-ever spacecraft to the far side of the Moon , Published online: 30 November 2018; doi:10.1038/d41586-018-07562-z Chang’e-4 mission will test plant growth on the Moon, and listen for radio emissions normally blocked by Earth's atmosphere.

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Love, death and CRISPR: an artwork Love, death and CRISPR: an artwork, Published online: 30 November 2018; doi:10.1038/d41586-018-07574-9 A collaboration between geneticists and an artist invites us through the looking glass into a speculative future, finds Anna Kriebs.

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Female authors draw more student readers than do male authors Female authors draw more student readers than do male authors, Published online: 29 November 2018; doi:10.1038/d41586-018-07605-5 Female researchers’ scientific impact might be undervalued by citation metrics in some countries.

A warning of future years both hot and dry A warning of future years both hot and dry, Published online: 29 November 2018; doi:10.1038/d41586-018-07567-8 A double whammy of heat and aridity is now more likely to strike regions around the globe.

UN treaty agrees to limit gene drives but rejects a moratorium UN treaty agrees to limit gene drives but rejects a moratorium, Published online: 29 November 2018; doi:10.1038/d41586-018-07600-w Treaty's vague language on how researchers can release engineered organisms has both opponents and supporters of the technology claiming victory.

Algeria fossils cast doubt on East Africa as sole origin of stone tools Algeria fossils cast doubt on East Africa as sole origin of stone tools, Published online: 29 November 2018; doi:10.1038/d41586-018-07570-z The discovery pushes back the evidence of hominins in Algeria by 600,000 years, and suggests tool use arose in different parts of Africa independently.

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Author Correction: Reassessing evidence of life in 3,700-million-year-old rocks of Greenland Author Correction: Reassessing evidence of life in 3,700-million-year-old rocks of Greenland, Published online: 29 November 2018; doi:10.1038/s41586-018-0759-x Author Correction: Reassessing evidence of life in 3,700-million-year-old rocks of Greenland

Daily briefing: Mitochondrial DNA can come from fathers too Daily briefing: Mitochondrial DNA can come from fathers too, Published online: 29 November 2018; doi:10.1038/d41586-018-07598-1 In rare cases, children can inherit mitochondrial DNA from both parents. Plus: CRISPR-baby scientist presents his research and what life looks like after the digital revolution

Venice anti-flood gates could wreck lagoon ecosystem Venice anti-flood gates could wreck lagoon ecosystem, Published online: 29 November 2018; doi:10.1038/d41586-018-07372-3 Instead, researchers suggest injecting fluid cement or water below ground to lift the entire city.

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Asteroid-sampling mission zeroes in on tiny space rock Asteroid-sampling mission zeroes in on tiny space rock, Published online: 29 November 2018; doi:10.1038/d41586-018-07563-y US spacecraft aims to return the largest trove of space dirt to Earth since NASA's final Apollo mission in the 1970s.

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Prehistoric Europeans feasted on caviar Prehistoric Europeans feasted on caviar, Published online: 28 November 2018; doi:10.1038/d41586-018-07541-4 Pottery fragments hint at how ancient cooks prepared the fishy delicacy.

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Location matters for insulin-producing cells Location matters for insulin-producing cells, Published online: 28 November 2018; doi:10.1038/d41586-018-07490-y Intrinsic and extrinsic cues drive dynamic processes that control cell fate during organ development. A study of mouse and human cells reveals how these inputs affect cells that make the essential hormone insulin.

Past warming events in the Arctic linked to shifting winds in the Antarctic Past warming events in the Arctic linked to shifting winds in the Antarctic, Published online: 28 November 2018; doi:10.1038/d41586-018-07495-7 During the most recent ice age, abrupt changes in the Arctic climate were transmitted through the ocean to Antarctica. An atmospheric link between the two hemispheres has now been identified across the Antarctic continent.

CDK12 regulates DNA repair genes by suppressing intronic polyadenylation CDK12 regulates DNA repair genes by suppressing intronic polyadenylation, Published online: 28 November 2018; doi:10.1038/s41586-018-0758-y The kinase CDK12 suppresses usage of intronic polyadenylation sites and thereby promotes the expression of genes involved in homologous recombination DNA repair.

Extreme-ultraviolet refractive optics Extreme-ultraviolet refractive optics, Published online: 28 November 2018; doi:10.1038/s41586-018-0737-3 A refractive lens and a refractive prism for extreme-ultraviolet radiation have been developed that use the deflection of the radiation in an inhomogeneous jet of atoms.

FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells, Published online: 28 November 2018; doi:10.1038/s41586-018-0756-0 PD-1 undergoes internalization, FBXO38-mediated ubiquitination and proteasome degradation in activated T cells, and inhibition of this pathway dampens anti-tumour immunity of T cells.

CRISPR-baby scientist fails to satisfy critics CRISPR-baby scientist fails to satisfy critics, Published online: 28 November 2018; doi:10.1038/d41586-018-07573-w He Jiankui gives talk about controversial genome-edited baby claim, but ethical questions remain.

Daily briefing: The paralyzed pioneers of brain–computer interfaces Daily briefing: The paralyzed pioneers of brain–computer interfaces, Published online: 28 November 2018; doi:10.1038/d41586-018-07578-5 From simply holding hands to flying a drone swarm. Plus: nations must triple their efforts to curb greenhouse gas and how to stomp out the shoddy statistics in personalized medicine.

Metabolic reprogramming by the S -nitroso-CoA reductase system protects against kidney injury Metabolic reprogramming by the <i>S</i>-nitroso-CoA reductase system protects against kidney injury, Published online: 28 November 2018; doi:10.1038/s41586-018-0749-z AKR1A1-regulated protein S-nitrosylation protects against kidney injury through PKM2-mediated metabolic reprogramming.

A glimpse into the heart of a quasar A glimpse into the heart of a quasar, Published online: 28 November 2018; doi:10.1038/d41586-018-07538-z Astronomical objects called quasars have been difficult to study because of the limited spatial resolution of observations. An approach has been developed that allows the structure and dynamics of quasars to be investigated.

Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1 Stella safeguards the oocyte methylome by preventing de novo methylation mediated by DNMT1, Published online: 28 November 2018; doi:10.1038/s41586-018-0751-5 Stella, a factor essential for female fertility, protects the oocyte methylome in mice by suppressing de novo DNA methylation mediated by the DNA methyltransferase DNMT1.

How cells hush a viral invader How cells hush a viral invader , Published online: 28 November 2018; doi:10.1038/d41586-018-07493-9 Viruses can insert a copy of their genetic sequence into a host cell’s genome. If the insertion fails, gene expression of unintegrated viral DNA in the nucleus is silenced. How this process occurs has now been uncovered.